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React was established in 1990. Its history is that of a label that tells the story of how acid house and club culture came of age. As React grew into one of the most successful and long-running independent dance labels in Britain, so did dance music. As Danny Rampling attested, "React has stood the test of time in the industry, proving to be front runners in providing first-class quality product."

On the 24th June 2004 React's James Horrocks and Melissa Kemp purchased the React Music brand, trademark and recordings catalog, they continue to operate it to the present day via React Music. Resist Music was set up in 2005 to release compilations. It was purchased in Sep 2009 by Phoenix Music International and is now a non related entity.